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Recombinant protein purification for structural and kinetic studies: a case study using M. tuberculosis a-methylacyl-CoA racemase (MCR) / Otsile O. Mojanaga, K Ravi Acharya, and Matthew D. Lloyd -- Steady-state kinetic analysis of reversible enzyme inhibitors: a case study on calf alkaline phosphatase / Henry Brooke, Meghna Ghoshray, Archad Ibrahim, and Matthew D. Lloyd -- Non-equilibrium modalities of inhibition: characterizing irreversible inhibition for the ErbB receptor family members / Bharath Srinivasan -- Analysis of continuous enzyme kinetic data using ICEKAT / Karina L. Bursch, Michael D. Olp, and Brian C. Smith -- You get what you screen for: standards for experimental design and data fitting n drug discovery / Kenneth A. Johnson -- Analysis of enzyme reactions using NMR techniques: a case study with a-methylacyl-CoA racemase (AMACR) / Timothy J. Woodman and Matthew D. Lloyd -- Crystallographic fragment screening in academic cancer drug discovery / Mathew P. Martin, Jane A. Endicott, Martin E.M. Noble, and Natalie J. Tatum -- Fast fragment and compound screening pipeline at the Swiss Light Source / Dennis Peter Stegmann, Julia Steuber, Günter Fritz, Justyna Aleksandra Wojdyla, and May Elizabeth Sharpe -- Fragment-based screening by protein-detected NMR spectroscopy / Paul J. Kerber, Raymundo Nuñez, Davin R. Jensen, Angela L. Zhou, Francis C. Peterson, R. Blake Hill, Brian F. Volkman, and Brian C. Smith -- Methods for computer-assisted PROTAC design / Evianne Rovers and Matthieu Schapira -- High-throughput cytochrome P450 loss and metabolic intermediate complex assays to aid in designing out of CYP3A inactivation / Drake A. Russell and Matthew A. Cerny -- Discovery and development of inhibitors of acetyltransferase Eis to combat Mycobacterium tuberculosis / Allan H. Pang, Keith D. Green, Oleg V. Tsodikov, and Sylvie Garneau-Tsodikova -- Design and evaluation of substrate-product analog inhibitors for racemases and epimerases utilizing a 1,1-proton transfer mechanism / Stephen L. Bearne -- Identification and biochemical characterization of small molecule inhibitors of ERK2 that target the D-recruitment site / R.M. Sammons, E.J. Cho, and K.N. Dalby -- Preparing recombinant "split AEP" for protein labeling / Muge Ma, Simon T.M. Tang, Matthew T. Dickerson, and Louis Y.P. Luk -- Mass cytometry as a tool in target validation and drug discovery / Edmund C.R. Watson, Warren Baker, David Ahern, Danson Loi, Adam P. Cribbs, and Udo Oppermann. |